ENPP2 CLIA Kit for Human(Homo sapiens) | EIAab.comENPP2 CLIA Kit for Human(Homo sapiens)

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ENPP2 (Gene name),

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Protein name ), ENPP2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ENPP2(ATX;PDNP2);

Protein name:

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2(E-NPP 2);

Alternative:

Extracellular lysophospholipase D(LysoPLD);Autotaxin;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.

Subcellular Location:

Secreted Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells.

Protein Attributes:

Sequence length:

863

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

863:

TLKTYLHTYE | SEI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.190977

String:

Q13822

MIM:

601060

Pfam:

PF01223

SMR:

Q13822

KEGG:

hsa:5168

Uniprot:

Q13822

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ELISA Kit for Human E-NPP 2

Cat.:

E1228m

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96T

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ELISA Kit for Human E-NPP 2

Cat.:

E1228h

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96T

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ELISA Kit for Human E-NPP 2

Cat.:

E1228b

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96T

ELISA Kit for Human E-NPP 2

Cat.:

E1228r

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Packing:

96T

CLIA Kit for Human E-NPP 2

Cat.:

U1228b

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Packing:

96T

CLIA Kit for Human E-NPP 2

Cat.:

U1228r

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Packing:

96T

CLIA Kit for Human E-NPP 2

Cat.:

U1228h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human E-NPP 2

Cat.:

U1228m

Price:

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Manual:

Looking for manual.

MSDS:

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96T

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Polyclonal Antibody for Human E-NPP 2

Cat.:

P1228Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human E-NPP 2

Cat.:

P1228Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human E-NPP 2

Cat.:

P1228Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human E-NPP 2

Monoclonal Antibody for Human E-NPP 2

Protein for Human E-NPP 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases."
Murata J. , Lee H.Y. , Clair T. , Krutzsch H.C. , Arestad A.A. , Sobel M.E. , Liotta L.A. , Stracke M.L.
J. Biol. Chem.269:30479-30484(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PARTIAL PROTEIN SEQUENCE;CHARACTERIZATION;VARIANT PRO-493
tissue: Melanoma.
2.

"Molecular cloning and chromosomal assignment of the human brain-type phosphodiesterase I/nucleotide pyrophosphatase gene (PDNP2)."
Kawagoe H. , Soma O. , Goji J. , Nishimura N. , Narita M. , Inazawa J. , Nakamura H. , Sano K.
Genomics30:380-384(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45;TISSUE SPECIFICITY;VARIANT PRO-493
3.

"Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells."
Lee H.Y. , Murata J. , Clair T. , Polymeropoulos M.H. , Torres R. , Manrow R.E. , Liotta L.A. , Stracke M.L.
Biochem. Biophys. Res. Commun.218:714-719(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;VARIANT PRO-493
tissue: Teratocarcinoma.
4.

"Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate."
van Meeteren L.A. , Ruurs P. , Christodoulou E. , Goding J.W. , Takakusa H. , Kikuchi K. , Perrakis A. , Nagano T. , Moolenaar W.H.
J. Biol. Chem.280:21155-21161(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;ENZYME REGULATION;VARIANT PRO-493
5.

"Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization."
Giganti A. , Rodriguez M. , Fould B. , Moulharat N. , Coge F. , Chomarat P. , Galizzi J.-P. , Valet P. , Saulnier-Blache J.-S. , Boutin J.A. , Ferry G.
J. Biol. Chem.283:7776-7789(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);PROTEIN SEQUENCE OF 36-42 AND 49-54;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY;VARIANT PRO-493
tissue: Brain.
tissue: Melanoma.
6.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PRO-493
tissue: Testis.
8.

"Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase."
Tokumura A. , Majima E. , Kariya Y. , Tominaga K. , Kogure K. , Yasuda K. , Fukuzawa K.
J. Biol. Chem.277:39436-39442(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 36-49; 318-330; 335-344; 440-450 AND 854-863;IDENTIFICATION;BIOPHYSICOCHEMICAL PROPERTIES
9.

"Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein."
Stracke M.L. , Krutzsch H.C. , Unsworth E.J. , Aarestad A. , Cioce V. , Schiffmann E. , Liotta L.A.
J. Biol. Chem.267:2524-2529(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 256-266; 370-392; 457-463; 481-496; 501-510; 545-554; 639-643; 706-710 AND 829-840;FUNCTION;VARIANT PRO-493
tissue: Melanoma.
10.

"Autotaxin (NPP-2), a metastasis-enhancing mitogen, is an angiogenic factor."
Nam S.W. , Clair T. , Kim Y.S. , McMarlin A. , Schiffmann E. , Liotta L.A. , Stracke M.L.
Cancer Res.61:6938-6944(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANGIOGENESIS
11.

"Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression."
Boucher J. , Quilliot D. , Pradere J.P. , Simon M.F. , Gres S. , Guigne C. , Prevot D. , Ferry G. , Boutin J.A. , Carpene C. , Valet P. , Saulnier-Blache J.S.
Diabetologia48:569-577(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;POSSIBLE FUNCTION IN OBESITY
12.

"Structural basis of substrate discrimination and integrin binding by autotaxin."
Hausmann J. , Kamtekar S. , Christodoulou E. , Day J.E. , Wu T. , Fulkerson Z. , Albers H.M. , van Meeteren L.A. , Houben A.J. , van Zeijl L. , Jansen S. , Andries M. , Hall T. , Pegg L.E. , Benson T.E. , Kasiem M. , Harlos K. , Kooi C.W. , more...
Nat. Struct. Mol. Biol.18:198-204(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;MUTAGENESIS OF THR-210; PHE-211; ALA-218; ASN-231 AND TYR-307

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